Update: I have installed the new Geforce 340.52 WHQL driver and finally there's good progress in this matter!
screen flickering in G-Sync mode w/ high res downsampling @ 60hz (or any other res/hz combination) is completely gone, fixed !
however, I stumble into another issue now, which is fortunately manageable.
I only tested a couple of games and it appears that when switching from a G-Sync 60hz downsampled resolution (say 3840x2160 or 3200x1800) straight to native 1080p @ 144hz G-Sync mode (in-game) OR normal mode (exit to desktop), monitor sometimes lose signal, going completely black, requiring a hard reset (system feels freeze in this state).
playing around with it some more I find two options to overcome this:
1. gradually lower resolution (increase refresh rate) in-game, say from 2160p@60hz to 1620p@85hz so only afterwards I may exit to desktop or go 1080p@144hz in-game. (note that I use "preferred refresh rate: maximum available" set globally in NVCP).
2. set desktop refresh rate to 60hz before launching a game set to 2160p or 1800p @ 60hz so it won't freeze when exiting back to desktop.
there might be other ways to go around it as I haven't tested thoroughly. anyway the above methods makes those ultra downsampling resolutions + g-sync usable at last, considering your hardware can push it

nevertheless, hope this new quirk get sorted out as well with future drivers.